Vitamin C Dosing for MCAS: How Much Should You Take and How Often?

Vitamin C Dosing for MCAS: How Much Should You Take and How Often?

Vitamin C is widely used as a natural mast cell stabiliser. It helps break down histamine, reduces inflammation and supports the immune system. But many people with MCAS are unsure about the right dose or whether they should take it once daily or twice daily.

Because vitamin C is water-soluble and leaves the body quickly, the size of the dose and the timing both matter.

What Dose Works Best for MCAS?

The most common effective range for MCAS is:

500 mg to 1000 mg, taken twice daily.

This provides steady support over the day without overwhelming the gut.

Here is how the dosing typically works:

Low sensitivity or starting dose:• 250 mg twice daily• Slowly increase as tolerated

Standard MCAS support dose:• 500 mg twice daily• (Total daily amount 1000 mg)

Higher support dose:• 1000 mg twice daily• (Total daily amount 2000 mg)• Useful during flares, infections or high-histamine days

Most adults do well in the middle range. More is not always better, especially if it causes bowel looseness.

Why Not Take 1000 mg Once Daily?

Taking vitamin C once daily causes:

• A quick rise in blood levels• A fast drop within a few hours

• A gap later in the day when mast cells have no support

• Short-lived symptom relief

This is not ideal for MCAS

, where mast cells tend to overreact throughout the day.

Splitting the same total dose into twice-daily dosing keeps levels steady and supports mast cells for longer.

How To Take It

• Take it in a liquid or powdered form if you have gut sensitivities

.• Take with food if you get stomach irritation

.• Choose non-acidic (buffered) vitamin C if you experience loose bowels

.• Hydrate well to support histamine clearance

.• Increase your dose slowly over several days if you are sensitive.

When To Adjust the Dose

Increase slightly if you have:

• A flare

• A cold, infection or high stress• High-histamine meals• Sinus congestion• Skin reactions

Decrease if you have:

• Loose bowels• Cramping• Gut irritation

Summary

For MCAS, vitamin C works best when taken in split doses. The typical range is 500 to 1000 mg twice daily, depending on sensitivity and symptom load. This keeps vitamin C levels steady, supports histamine breakdown and provides more reliable mast cell stability across the day.

Dr Purity Carr

10:10 Menopause and Lifestyle Metabolic Reset

Menopause Momentum Network

www.purity.health

www.menopausemomentumnetwork.com